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Article

Efavirenz intoxication due to slow hepatic metabolism.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Feb 2005

Hasse B, Günthard H F, Bleiber G, Krause M

Abstract excerpt

We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.

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Identifiers

PMID: 15668854
DOI: 10.1086/427031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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