Article
Single-gene knockout of a novel regulatory element confers ethionine resistance and elevates methionine production in Corynebacterium glutamicum.
Applied microbiology and biotechnology - 1 Aug 2005
Mampel Jörg, Schröder Hartwig, Haefner Stefan, Sauer Uwe
Abstract excerpt
Despite the availability of genome data and recent advances in methionine regulation in Corynebacterium glutamicum, sulfur metabolism and its underlying molecular mechanisms are still poorly characterized in this organism. Here, we describe the identification of an ORF coding for a putative regulatory protein that controls the expression of genes involved in sulfur reduction dependent on extracellular methionine...
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