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Article

The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis.

FEMS yeast research - 1 May 2003

Kruppa Michael, Goins Tresa, Cutler Jim E, Lowman Douglas, Williams David, Chauhan Neeraj, Menon Veena, Singh Praveen, Li Dongmei, Calderone Richard

Abstract excerpt

The human pathogen Candida albicans encodes at least three putative two-component histidine kinase signal transduction proteins, including Chk1p and a response regulator protein (Cssk1p). Strains deleted in CHK1 are avirulent in a murine model of hematogenously disseminated disease. The specific function of Chk1p has not been established, but hyphae of the chk1 mutant exhibit extensive flocculation while yeast...

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PMID: 12689636
DOI: 10.1111/j.1567-1364.2003.tb00170.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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