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Article

Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS).

Protein science : a publication of the Protein Society - 1 Sept 2003

Zawadzki Kerri M, Hamuro Yoshitomo, Kim Jack S, Garrod Siv, Stranz David D, Taylor Susan S, Woods Virgil L

Abstract excerpt

cAMP-dependent protein kinase (cAPK) is a heterotetramer containing a regulatory (R) subunit dimer bound to two catalytic (C) subunits and is involved in numerous cell signaling pathways. The C-subunit is activated allosterically when two cAMP molecules bind sequentially to the cAMP-binding domai...

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Identifiers

PMID: 12930997
DOI: 10.1110/ps.03166903
PMCID: PMC2323995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12930997-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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