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Article

The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18

1 Jan 2005

Abstract excerpt

BACKGROUND: ADAM12-S is a pregnancy-associated insulin-like growth factor binding protein-3 (IGFBP-3) and IGFBP-5 protease present in human gestational serum. Recently, maternal serum levels of ADAM12-S were found to be markedly reduced during the first trimester of pregnancies with a Down syndrome (DS) fetus. On the basis of this finding, it was suggested that ADAM12-S might be a useful maternal serum marker of...

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Share to Gestational Trophoblastic Disease Studies
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PMID: 15662668
DOI: 10.1002/pd.1029

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