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Screening of Maternal Serum for Fetal Down's Syndrome in the First Trimester

2 Apr 1998

Abstract excerpt

BACKGROUND: Screening of maternal serum to identify fetuses with Down's syndrome is now routinely offered during the second trimester of pregnancy. Prenatal screening by means of serum assays or ultrasonographic measurements, either alone or in combination, may also be possible in the first trimester. METHODS: We measured serum alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin (hCG), the free...

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PMID: 9521983
DOI: 10.1056/nejm199804023381404

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