Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer

26 Feb 2020

Abstract excerpt

In colorectal cancer (CRC), upregulation of the C-X-C motif chemokine receptor 4 (CXCR4) is correlated with metastasis and poor prognosis, highlighting the need to further elucidate CXCR4’s regulation in CRC. For the first time, DNA methylation and 5-hydroxymethylcytosine aberrations were investigated to better understand the epigenetic regulation of CXCR4 in CRC. CXCR4 expression levels were measured using qPCR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Epigenetics and DNA Methylation
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32110952
DOI: 10.3390/cancers12030539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal CancerPMID 32110952Read ↗

Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter MethylationSemantic proximity Read ↗

Data Mining Suggests that CXCL14 Gene Silencing in Colon Cancer is Due to Promoter MethylationSemantic proximity Read ↗

Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progressionSemantic proximity Read ↗

The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic CancerSemantic proximity Read ↗

Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon CancerSemantic proximity Read ↗

ZEB1 hypermethylation is associated with better prognosis in patients with colon cancerSemantic proximity Read ↗

Association of CXCR4 gene expression and promoter methylation with chronic hepatitis B-related fibrosis/cirrhosisSemantic proximity Read ↗

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulationSemantic proximity Read ↗

Epigenetic Changes of CXCR4 and Its Ligand CXCL12 as Prognostic Factors for Sporadic Breast CancerSemantic proximity Read ↗

C-X-C chemokine receptor type 5 gene polymorphism affects gene expression in CD4+ T cells and is associated with increased risk of colorectal cancer.Semantic proximity Read ↗

ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon CancerSemantic proximity Read ↗

Expression Profile and Prognostic Value of CXCR Family Members in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.