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Article

Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel γ subunit

1 Dec 2002

Abstract excerpt

OBJECTIVE: To characterize novel type of mutations of the epithelial sodium channel (ENaC) or subunits in patients with Liddle's syndrome, an autosomal dominant form of hypertension. PATIENTS AND METHODS: DNA samples from two probands with early-onset, treatment-resistant hypertension and suppressed plasma renin activity were initially screened for mutations in the C-terminal exons of the ENaC or subunit genes,...

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PMID: 12473862
DOI: 10.1097/00004872-200212000-00017

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Source receipt: pubmed, retrieved 7 Sept 2026.

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