Article
Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1998
Persu A, Barbry P, Bassilana F, Houot A M, Mengual R, Lazdunski M, Corvol P, Jeunemaitre X
Abstract excerpt
Mutations of the last exon of the beta subunit of the amiloride-sensitive epithelial Na+ channel (betaENaC) can lead to Liddle's syndrome, a rare monogenic form of hypertension. The objective of this study was to test whether more subtle changes of betaENaC could be implicated in essential hypert...
Topics
- Adult
- Animals
- Base Sequence
- Epithelium
- Exons
- Female
- Genetic Variation
- Humans
- Hypertension
- Introns
- Male
- Middle Aged
- Molecular Sequence Data
- Mutagenesis
- Oocytes
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational