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Article

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.

Hepatology (Baltimore, Md.) - 1 Feb 2005

Baumert Thomas F, Yang Chun, Schürmann Peter, Köck Josef, Ziegler Christian, Grüllich Carsten, Nassal Michael, Liang T Jake, Blum Hubert E, von Weizsäcker Fritz

Abstract excerpt

Hepatitis B virus (HBV) core promoter mutations have been implicated in the pathogenesis of fulminant hepatitis B. Due to the limited availability of primary human hepatocytes, the functional characterization of HBV mutants has been performed predominantly in transformed cells, which may not represent ideal model systems for studying virus-cell interactions. We and others have shown that primary hepatocytes of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 15660384
DOI: 10.1002/hep.20553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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