Article

Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection

2002-01-15

Abstract excerpt

Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide, but the study of HCV infection has been hampered by the lack of an in vitro or in vivo small animal model. The tree shrew Tupaia belangeri is susceptible to infection with a variety of human viruses in vivo, including hepatitis viruses. We show that primary Tupaia hepatocytes can be infected with serum- or plasma-derived HCV from infected hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0449ab10-010f-5cd2-af8c-8c8886b6a623
DOI: 10.1172/jci0213011

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infectionDOI 10.1172/jci0213011Read

Tree shrew, a potential animal model for hepatitis C, supports the infection and replication of HCV in vitro and in vivoSemantic proximity Read

Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma.Semantic proximity Read

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.Semantic proximity Read

Animal model for hepatitis C virus infection.Semantic proximity Read

Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary<i>Tupaia</i>HepatocytesSemantic proximity Read

Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization.Semantic proximity Read

Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?Semantic proximity Read

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells.Semantic proximity Read

Viral and cellular determinants involved in hepadnaviral entrySemantic proximity Read

Animal Models Used in Hepatitis C Virus ResearchSemantic proximity Read

Sodium Taurocholate Cotransporting Polypeptide Mediates Woolly Monkey Hepatitis B Virus Infection of Tupaia HepatocytesSemantic proximity Read

A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivaxSemantic proximity Read