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Article

Hypergravity stimulates osteoblast phenotype expression: a therapeutic hint for disuse bone atrophy.

Annals of the New York Academy of Sciences - 1 Dec 2004

Morita Sadao, Nakamura Hiroshi, Kumei Yasuhiro, Shimokawa Hitoyata, Ohya Keiichi, Shinomiya Kenichi

Abstract excerpt

Physiological actions of osteoblasts are disordered by gravity unloading. We investigated the possibility that the appropriate level of hypergravity could improve osteoblast functions that are susceptible to mechanical unloading. We evaluated hypergravity effects on the 1alpha,25-dihydroxyvitamin D(3) (VD)-inducible osteocalcin expression of primary rat osteoblasts. Cell culture plates were centrifuged for 24 h...

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PMID: 15659793
DOI: 10.1196/annals.1329.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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