Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio.

Journal of cellular biochemistry - 1 Feb 2007

Rucci Nadia, Rufo Anna, Alamanou Marina, Teti Anna

Abstract excerpt

Mechanical unloading causes detrimental effects on the skeleton, but the underlying mechanisms are still unclear. We investigated the effect of microgravity on osteoblast ability to regulate osteoclastogenesis. Mouse osteoblast primary cultures were grown for 24 h at unit gravity or under simulat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Bone Resorption
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Osteoclasts

Share to Osteoprotegerin

Share to RANK Ligand

Share to Weightlessness

Source

Identifiers

PMID: 16927271
DOI: 10.1002/jcb.21059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16927271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio.PMID 16927271Read ↗

Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation.Semantic proximity Read ↗

Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV).Semantic proximity Read ↗

Osteocytes and WeightlessnessSemantic proximity Read ↗

Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cellsSemantic proximity Read ↗

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration.Semantic proximity Read ↗

SCD – Stem Cell Differentiation Toward Osteoblast Onboard the International Space StationSemantic proximity Read ↗

What do we know about alteration in the osteoblast phenotype with microgravity?Semantic proximity Read ↗

The Effects of Weightlessness on the Human Organism and Mammalian CellsSemantic proximity Read ↗

The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics StudySemantic proximity Read ↗

Physiological effects of microgravity on osteoblast morphology and cell biology.Semantic proximity Read ↗

Modeled gravitational unloading triggers differentiation and apoptosis in preosteoclastic cellsSemantic proximity Read ↗

Osteoblast differentiation is enhanced in rotary cell culture simulated microgravity environments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.