Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation.

Journal of cellular biochemistry - 15 Feb 2003

Ontiveros C, McCabe Laura R

Abstract excerpt

Conditions of disuse such as bed rest, space flight, and immobilization result in decreased mechanical loading of bone, which is associated with reduced bone mineral density and increased fracture risk. Mechanisms involved in this process are not well understood but involve the suppression of osteoblast function. To elucidate the influence of mechanical unloading on osteoblasts, a rotating wall vessel (RWV) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Alkaline Phosphatase
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 1 Subunit

Share to Osteoblasts

Share to Osteocalcin

Share to Space Flight

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 12532319
DOI: 10.1002/jcb.10410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation.PMID 12532319Read ↗

Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio.Semantic proximity Read ↗

Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV).Semantic proximity Read ↗

The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics StudySemantic proximity Read ↗

Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cellsSemantic proximity Read ↗

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration.Semantic proximity Read ↗

What do we know about alteration in the osteoblast phenotype with microgravity?Semantic proximity Read ↗

Physiological effects of microgravity on osteoblast morphology and cell biology.Semantic proximity Read ↗

SCD – Stem Cell Differentiation Toward Osteoblast Onboard the International Space StationSemantic proximity Read ↗

Osteocytes and WeightlessnessSemantic proximity Read ↗

Runx2 Is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in VivoSemantic proximity Read ↗

Osteoblast differentiation is enhanced in rotary cell culture simulated microgravity environments.Semantic proximity Read ↗

Hypergravity stimulates osteoblast phenotype expression: a therapeutic hint for disuse bone atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.