Article
Significant association of insertion/deletion polymorphism of the angiotensin-converting enzyme gene with rheumatoid arthritis.
The Journal of rheumatology - 1 Dec 2007
Uppal Sukhbir S, Haider Mohammad Z, Hayat Sawsan J, Abraham Mini, Sukumaran Jalaja, Dhaunsi Gursev S
Abstract excerpt
OBJECTIVE: Only 30% of the genetic contribution to rheumatoid arthritis (RA) can be attributed to HLA genes, and other non-HLA genes may play a role in RA susceptibility. Angiotensin-converting enzyme (ACE) has been reported to be involved in pathogenesis of RA, and high levels of ACE have been documented in RA synovial fluid and pleural effusions. Since plasma and tissue levels of ACE are determined at the...
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