Article
Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis.
The Journal of investigative dermatology - 1 Jan 2005
Foerster John, Nolte Ilja, Junge Judith, Bruinenberg Marcel, Schweiger Susann, Spaar Katja, van der Steege Gerrit, Ehlert Claudia, Mulder Marcel, Kalscheuer Vera, Blumenthal-Barby Elisa, Winter Jennifer, Seeman Petra, Ständer Markward, Sterry Wolfram, Te Meerman Gerard
Abstract excerpt
The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2. By re-analyzing a published data set with a previously developed method, the haplotype sharing statistic, we confirm localization of PSORS1 to the RH1 region and refine its location to marker M6S168. We replicate this result in an independent...
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