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Article

Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility.

The Journal of investigative dermatology - 1 Jul 2012

Lai Olivia Y, Chen Haoyan, Michaud Henri-Alexandre, Hayashi Genki, Kuebler Peter J, Hultman Gustaf K, Ariza Maria-Eugenia, Williams Marshall V, Batista Mariana D, Nixon Douglas F, Foerster John, Bowcock Anne M, Liao Wilson

Abstract excerpt

Previous genetic and functional studies have implicated the human endogenous retrovirus K (HERV-K) dUTPase located within the PSORS1 locus in the major histocompatibility complex region as a candidate psoriasis gene. Here, we describe a variant discovery and case-control association study of HERV-K dUTPase variants in 708 psoriasis cases and 349 healthy controls. Five common HERV-K dUTPase variants were found to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22437317
DOI: 10.1038/jid.2012.69
PMCID: PMC3375357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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