Article
PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2005
Li Jianping, Wang Xiaobin, Huo Yong, Niu Tianhua, Chen Changzhong, Zhu Guoying, Huang Yinmin, Chen Dafang, Xu Xiping
Abstract excerpt
PURPOSE: Previous studies on PON1 gene polymorphism and the risk of coronary atherosclerotic diseases have been inconsistent. This may be in part due to population difference in prevalence of high oxidative stress and its modifying effect on the association. Diabetes and obesity are two major risk factors of myocardial infarction (MI) and associated with high oxidative stress. We investigated the association...
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