Article
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.
Molecules and cells - 31 Dec 2004
Kim Dae Won, Yoon Chang Sik, Eum Won Sik, Lee Byung Ryong, An Jae Jin, Lee Sun Hwa, Lee Seung Ree, Ahn Jee-Yin, Kwon Oh-Shin, Kang Tae-Cheon, Won Moo Ho, Cho Sung-Woo, Lee Kil Soo, Park Jinseu, Choi Soo Young
Abstract excerpt
gamma-Aminobutyrate transaminase (GABA-T), a key enzyme of the GABA shunt, converts the major inhibitory neurotransmitter, GABA, to succinic semialdehyde. Although GABA-T is a pivotal factor implicated in the pathogenesis of various neurological disorders, its function remains to be elucidated. In an effort to clarify the structural and functional roles of specific lysyl residue in human brain GABA-T, we...
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