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Article

Might erectile dysfunction be due to the thermolabile variant of methylenetetrahydrofolate reductase?

Journal of endocrinological investigation - 1 Oct 2004

Lombardo F, Sgrò P, Gandini L, Dondero F, Jannini E A, Lenzi A

Abstract excerpt

Hyperhomocysteinemia is considered one of the most important cardiovascular risk factors increasing considerably the risk of stroke and myocardial infarction. With respect to endothelial function, direct effects of hyperhomocysteinemia on vascular endothelial cells have been demonstrated through the reduction of endothelial nitric oxide production. In this paper, we report the case of a young man with homozygote...

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Identifiers

PMID: 15648556
DOI: 10.1007/BF03346286

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Might erectile dysfunction be due to the thermolabile variant of methylenetetrahydrofolate reductase?PMID 15648556Read ↗

Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i.Semantic proximity Read ↗

[Is the thermolabile variant of methylenetetrahydrofolate reductase a risk factor of arterial and venous thrombosis?].Semantic proximity Read ↗

Mutation in the methylenetetrahydrofolate reductase gene might be a risk factor for cerebrovascular disease in peripartum and under oral contraceptive use.Semantic proximity Read ↗

[Vascular diseases, spina bifida and schizophrenia in a single family associated with the heterozygote mutation of the heat-sensitive variant of methylenetetrahydrofolate reductase].Semantic proximity Read ↗

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.Semantic proximity Read ↗

Role of methylenetetrahydrofolate reductase gene polymorphisms (C677T, A1298C, and G1793A) in the development of early onset vasculogenic erectile dysfunction.Semantic proximity Read ↗

A common haplotype for the 677T thermolabile variant of the 5,10-methylenetetrahydrofolate reductase gene in thrombophilic patients and controls.Semantic proximity Read ↗

5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis.Semantic proximity Read ↗

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Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.Semantic proximity Read ↗

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