Article
Genetic diagnosis of claudin-16 deficiency and sex determination in bovine preimplantation embryos.
The Journal of reproduction and development - 1 Dec 2004
Hirayama Hiroki, Kageyama Soichi, Moriyasu Satoru, Hirano Takashi, Sugimoto Yoshikazu, Kobayashi Naohiko, Inaba Mutsumi, Sawai Ken, Onoe Sadao, Minamihashi Akira
Abstract excerpt
Renal tubular dysplasia is an autosomal recessively inherited disorder in Japanese black cattle that is due to deletion mutations in the claudin-16 gene and causes chronic renal failure and death of affected animals. Here, we report a multiplex-PCR procedure to determine the genotype for claudin-16 deficiency in preimplantation embryos. The presence or absence of the wild-type and mutant allele(s) was precisely...
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