Article
Abnormal development of nephrons in claudin-16-defective Japanese black cattle.
The Journal of veterinary medical science - 1 Feb 2005
Okada Kosuke, Ishikawa Naoko, Fujimori Kouichiro, Goryo Masanobu, Ikeda Manabu, Sasaki Jun, Watanabe Daisaku, Takasuga Akiko, Hirano Takashi, Sugimoto Yoshikazu
Abstract excerpt
The kidneys of 37 Japanese Black calves aged 2 to 65 months diagnosed with Claudin 16 (CL-16) defect by the DNA-based test were examined pathologically. The animals exhibited clinical symptoms such as growth impairment, renal failure, overgrowth of hooves, and anemia at a young age. There was no correlation between the time of onset and age. Kidney weights relative to body weight were similar to those in normal...
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