Article
DNA adducts and other biological markers in risk assessment for environmental carcinogens.
Annali dell'Istituto superiore di sanita - 1 Jan 1991
Perera F, Mayer J, Santella R M, Brenner D, Tsai W Y, Brandt-Rauf P, Hemminki K
Abstract excerpt
In order to validate a number of biologic markers as indicators of effective dose or potential risk, we have applied them in related cross-sectional, longitudinal and case-control studies. Biologic markers such as carcinogen-DNA adducts and activated oncogenes have already provided insights into mechanisms of chemical carcinogenesis. They have also given information regarding the extent of interindividual...
Topics
- Biomarkers
- Carcinogenicity Tests
- Carcinogens, Environmental
- Case-Control Studies
- DNA Damage
- DNA Repair
- Genetic Variation
- Lung Neoplasms
- Occupational Diseases
- Oncogenes
- Polycyclic Compounds