Article
Evidence of a correlation between mannose binding lectin and celiac disease: a model for other autoimmune diseases.
Journal of molecular medicine (Berlin, Germany) - 1 Apr 2005
Boniotto Michele, Braida Laura, Baldas Valentina, Not Tarcisio, Ventura Alessandro, Vatta Serena, Radillo Oriano, Tedesco Francesco, Percopo Selvaggia, Montico Marcella, Amoroso Antonio, Crovella Sergio
Abstract excerpt
Celiac disease is a multifactorial disorder caused, in genetically susceptible patients, by the ingestion of dietary gluten. Very little is known about the genetic factors, but there is a strong association of two HLA haplotypes (DQ2 or alpha1*05, beta1*02 and DQ8 or alpha1*0301, beta1*0302) with the disease. We investigated the relationship between polymorphisms in the first exon of the MBL2 gene, which encodes...
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