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Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.

Oncology reports - 1 Feb 2005

Shen Hongbing, Newmann Ana S, Hu Zhibin, Zhang Zhengdong, Xu Yaochu, Wang Liwei, Hu Xu, Guo Jiangtao, Wang Xinru, Wei Qingyi

Abstract excerpt

Studies have suggested that low dietary folate intake is associated with an increased risk of gastric cancer. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and influences DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level. We hypothesized that three MTHFR common...

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Identifiers

PMID: 15643524

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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