Article
[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Jan 2005
Hui Zhou-Guang, Li Ye-Xiong, Yang Wei-Zhi, Yu Zi-Hao
Abstract excerpt
BACKGROUND & OBJECTIVE: Irradiation often causes cell cycle arrest in tumor cells. This study was to observe the abrogation of radiation-induced G(2) phase arrest of p53 mutated human cancer cell lines by 7-hydroxystaurosporine (UCN-01), and explore the mechanism. METHODS: Human nasopharyngeal carcinoma cell line CNE-1 and human lung adenocarcinoma cell line 973, both with p53 mutation, were used in this study....
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