Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.

Radiation research - 1 Jul 2002

Xiao Helen H, Makeyev Yan, Butler James, Vikram Bhadrasain, Franklin William A

Abstract excerpt

Mutations in TP53 occur in more than 50% of the lung cancer patients and are associated with an increased resistance to chemotherapy and radiotherapy. The human lung adenocarcinoma cell lines A549 and LXSN contain a wild-type TP53 and were growth arrested at both the G(1)- and G(2)-phase checkpoints after irradiation. However, a TP53-disrupted cell line, E6, was arrested only at the G(2)-phase checkpoint. UCN-01...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Alkaloids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to G2 Phase

Share to Gamma Rays

Share to Radiation-Sensitizing Agents

Share to Staurosporine

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12071807
DOI: 10.1667/0033-7587(2002)158[0084:hupscw]2.0.co;2

Genes

UCN
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.PMID 12071807Read ↗

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogationSemantic proximity Read ↗

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.Semantic proximity Read ↗

[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].Semantic proximity Read ↗

[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].Semantic proximity Read ↗

Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.Semantic proximity Read ↗

siRNA Targeting NBS1 or XIAP Increases Radiation Sensitivity of Human Cancer Cells Independent of TP53 StatusSemantic proximity Read ↗

p53-independent structure-activity relationships of 3-ring mesogenic compounds’ activity as cytotoxic effects against human non-small cell lung cancer linesSemantic proximity Read ↗

Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.Semantic proximity Read ↗

Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint.Semantic proximity Read ↗

RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549Semantic proximity Read ↗

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.Semantic proximity Read ↗

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.