Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.

Cancer research - 15 Jul 2014

Hirokawa Takahisa, Shiotani Bunsyo, Shimada Midori, Murata Kazuhiro, Johmura Yoshikazu, Haruta Mayumi, Tahara Hidetoshi, Takeyama Hiromitsu, Nakanishi Makoto

Abstract excerpt

CBP-93872 was previously identified as a G2 checkpoint inhibitor using a cell-based high-throughput screening system. However, its molecular actions as well as cellular targets are largely unknown. Here, we uncovered the molecular mechanisms underlying abrogation of the G2 checkpoint by CBP-93872...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aniline Compounds
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to DNA Breaks, Double-Stranded

Share to Enzyme Activation

Share to G2 Phase Cell Cycle Checkpoints

Share to Phosphorylation

Share to Propanolamines

Source

Identifiers

PMID: 24876101
DOI: 10.1158/0008-5472.CAN-13-3604

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24876101-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.PMID 24876101Read ↗

Identification of a checkpoint modulator with synthetic lethality to p53 mutants.Semantic proximity Read ↗

Abrogation of the G2 Checkpoint by Inhibition of Wee-1 Kinase Results in Sensitization of p53-Deficient Tumor Cells to DNA-Damaging AgentsSemantic proximity Read ↗

Therapeutic Exploitation of Checkpoint Defects in Cancer Cells Lacking p53 FunctionSemantic proximity Read ↗

Molecular Basis for G2 Arrest Induced by 2′- C -Cyano-2′-Deoxy-1-β- d - Arabino -Pentofuranosylcytosine and Consequences of Checkpoint AbrogationSemantic proximity Read ↗

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.Semantic proximity Read ↗

G2 damage checkpoints: what is the turn-on?Semantic proximity Read ↗

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.Semantic proximity Read ↗

Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint.Semantic proximity Read ↗

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in CancerSemantic proximity Read ↗

Analyzing the G2/M checkpoint.Semantic proximity Read ↗

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1Semantic proximity Read ↗

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.