Significance of valine/leucine²⁴⁷ polymorphism of β₂‐glycoprotein I in antiphospholipid syndrome: Increased reactivity of anti–β₂‐glycoprotein I autoantibodies to the valine²⁴⁷ β₂‐glycoprotein I variant

Abstract excerpt

OBJECTIVE: To clarify the consequences of the valine/leucine polymorphism at position 247 of the beta(2)-glycoprotein I (beta(2)GPI) gene in patients with antiphospholipid syndrome (APS), by investigating the correlation between genotypes and the presence of anti-beta(2)GPI antibody. The reactivity of anti-beta(2)GPI antibodies was characterized using recombinant Val(247) and Leu(247) beta(2)GPI. METHODS:...

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