Article
A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome.
Arthritis and rheumatism - 1 Aug 1999
Hirose N, Williams R, Alberts A R, Furie R A, Chartash E K, Jain R I, Sison C, Lahita R G, Merrill J T, Cucurull E, Gharavi A E, Sammaritano L R, Salmon J E, Hashimoto S, Sawada T, Chu C C, Gregersen P K, Chiorazzi N
Abstract excerpt
OBJECTIVE: To determine the frequencies at which either a valine or leucine occurs at position 247 in the beta2-glycoprotein I (beta2GPI) gene of normal individuals of the Caucasian, African American, and Asian ethnic groups and to compare these data with those in patients with the antiphospholipid syndrome (APS), with and without anti-beta2GPI antibodies. METHODS: The DNA segment containing the position-247...
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