Preliminary physiologic characterization and genetic analysis of a new Escherichia coli mutant, lov, resistant to mecillinam.

doi:10.1093/clinids/10.4.905

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Article

Preliminary physiologic characterization and genetic analysis of a new Escherichia coli mutant, lov, resistant to mecillinam.

Reviews of infectious diseases - 1 Jan 2000

Bouloc P, Jaffé A, D'Ari R

Abstract excerpt

A mutant of Escherichia coli resistant to mecillinam was selected. The target of this antibiotic is penicillin-binding protein 2 (PBP2), which is active in cell wall elongation and responsible for the rod-like shape of the organism. Several observations indicate that PBP2 remains active in the mutant. For example, cells are small and rod-shaped in the absence of mecillinam but become spherical in its presence;...

Topics

Amdinocillin
Bacterial Proteins
Carrier Proteins
Culture Media
Cyclic AMP
Escherichia coli
Escherichia coli Proteins
Hexosyltransferases
Multienzyme Complexes
Muramoylpentapeptide Carboxypeptidase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Penicillin Resistance

Penicillin-Binding Proteins

Peptidyl Transferases

Phenotype

Ribosomal Protein S9

Transduction, Genetic

Source

Open in PubMed

Identifiers

PMID: 2847279
DOI: 10.1093/clinids/10.4.905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2847279-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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