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Article

Transcription-Based Prediction of Response to IFNβ Using Supervised Computational Methods

20 Dec 2004

Abstract excerpt

Changes in cellular functions in response to drug therapy are mediated by specific transcriptional profiles resulting from the induction or repression in the activity of a number of genes, thereby modifying the preexisting gene activity pattern of the drug-targeted cell(s). Recombinant human interferon beta (rIFNbeta) is routinely used to control exacerbations in multiple sclerosis patients with only partial...

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PMID: 15630474
DOI: 10.1371/journal.pbio.0030002

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