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Molecular Network Analysis of T‐Cell Transcriptome Suggests Aberrant Regulation of Gene Expression by NF‐κB As a Biomarker for Relapse of Multiple Sclerosis

1 Jan 2008

Abstract excerpt

Molecular mechanisms responsible for acute relapse of multiple sclerosis (MS) remain currently unknown. The aim of this study is to identify the relapse-specific biomarker genes in T lymphocytes of relapsing-remitting MS (RRMS). Total RNA of CD3+ T cells isolated from six RRMS patients taken at the peak of acute relapse and at the point of complete remission was processed for DNA microarray analysis. We...

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PMID: 18776589
DOI: 10.1155/2008/824640

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