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Baseline Gene Expression Signatures in Monocytes from Multiple Sclerosis Patients Treated with Interferon-beta

18 Apr 2013

Abstract excerpt

BACKGROUND: A relatively large proportion of relapsing-remitting multiple sclerosis (RRMS) patients do not respond to interferon-beta (IFNb) treatment. In previous studies with peripheral blood mononuclear cells (PBMC), we identified a subgroup of IFNb non-responders that was characterized by a baseline over-expression of type I IFN inducible genes. Additional mechanistic experiments carried out in IFNb...

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Immune cells in cancer
Immune Response and Inflammation
Multiple Sclerosis Research Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23637780
DOI: 10.1371/journal.pone.0060994

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