Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

3 Jan 2005

Abstract excerpt

Genes crucial for cancer development can be mutated via various mechanisms, which may reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding for effectors along the MAPK pathway are central for transformation. BRAF point mutation is most common in sporadic tumors. By contrast, radiation-induced tumors are associated with paracentric inversions activating the receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Melanoma and MAPK Pathways
Share to Thyroid Cancer Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15630448
DOI: 10.1172/jci23237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerPMID 15630448Read ↗

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerSemantic proximity Read ↗

Fusion Oncogenes Are the Main Genetic Events Found in Sporadic Papillary Thyroid Carcinomas from ChildrenSemantic proximity Read ↗

AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma.Semantic proximity Read ↗

Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.Semantic proximity Read ↗

Challenging Dogma in Thyroid Cancer Molecular Genetics—Role of<i>RET/PTC</i>and<i>BRAF</i>in Tumor InitiationSemantic proximity Read ↗

BRAF T1796A Transversion Mutation in Various Thyroid NeoplasmsSemantic proximity Read ↗

<i>RET/PTC</i> Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation DoseSemantic proximity Read ↗

AGK‐BRAF is associated with distant metastasis and younger age in pediatric papillary thyroid carcinomaSemantic proximity Read ↗

ETV6‐NTRK3 is a common chromosomal rearrangement in radiation‐associated thyroid cancerSemantic proximity Read ↗

Distinctive molecular features of radiation-induced thyroid cancers.Semantic proximity Read ↗

RET Oncogene Activation in Papillary Thyroid CarcinomaSemantic proximity Read ↗

Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.