The Crystal Structure of Mycobacterium tuberculosis Thymidylate Kinase in Complex with 3‘-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition,

Abstract excerpt

Tuberculosis (TB) is the primary cause of mortality among infectious diseases. Mycobacterium tuberculosis thymidylate kinase (TMPK(Mtub)) catalyzes the ATP-dependent phosphorylation of deoxythymidine 5'-monophosphate (dTMP). Essential to DNA replication, this enzyme represents a promising target for developing new drugs against TB, because the configuration of its active site is unique within the TMPK family....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to Enzyme Structure and Function
• Share to Tuberculosis Research and Epidemiology