Article
Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene.
Inflammatory bowel diseases - 1 Nov 2004
Bagnoli Siro, Putignano Anna Laura, Melean German, Baglioni Silvana, Sestini Roberta, Milla Monica, d'Albasio Giuseppe, Genuardi Maurizio, Pacini Franco, Trallori Giacomo, Papi Laura
Abstract excerpt
The hMLH1 gene lies in the linkage susceptibility region to inflammatory bowel disease (IBD) on 3p21. A single nucleotide polymorphism, 655A>G, in exon 8 of the gene causes an I219V change in the MLH1 protein. To test whether hMLH1 may confer susceptibility to ulcerative colitis (UC), we investigated an association between the 655A>G polymorphism and the disease. DNA-based technologies were used to analyze the...
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