Article
Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation.
Annals of neurology - 1 Nov 1997
Jackson M, Al-Chalabi A, Enayat Z E, Chioza B, Leigh P N, Morrison K E
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive paralytic disorder resulting from the degeneration of motor neurons in the brain and spinal cord and leading to death within 5 years of symptom onset. The great majority of ALS cases are sporadic, with the familial form (FALS) representing fewe...
Topics
- Alleles
- Amyotrophic Lateral Sclerosis
- Cloning, Molecular
- DNA Mutational Analysis
- Exons
- Humans
- Introns
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Superoxide Dismutase