Article
Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases - 1 Jun 2001
Chioza B A, Ujfalusy A, Csiszar K, Leigh P N, Powell J F, Radunović A
Abstract excerpt
BACKGROUND: There is an urgent need to identify genes involved in familial ALS (FALS), as mutations in the CuZn superoxide dismutase (SOD1) gene can account for 20% of FALS cases. The mechanisms by which the many mutations in the SOD1 gene lead to motoneuron degeneration are unknown, although current experimental evidence supports a toxic gain of function, possibly through copper-induced cytotoxicity. Copper is...
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