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Article

Pick bodies in a family with presenilin-1 Alzheimer's disease.

Annals of neurology - 1 Jan 2005

Halliday Glenda M, Song Yun Ju C, Lepar Gila, Brooks William S, Kwok John B, Kersaitis Cindy, Gregory Gillian, Shepherd Claire E, Rahimi Farid, Schofield Peter R, Kril Jillian J

Abstract excerpt

Presenilin-1 (PS-1) mutations can cause Pick's disease without evidence of Alzheimer's disease (AD). We describe a family with a PS-1 M146L mutation and both Pick bodies and AD. Sarkosyl-insoluble hyperphosphorylated tau showed three bands consistent with AD, although dephosphorylation showed primarily three-repeat isoforms. M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple...

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PMID: 15622541
DOI: 10.1002/ana.20366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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