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Article

p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid.

Mechanisms of ageing and development - 1 Feb 2005

Sagi Orli, Wolfson Marina, Utko Natalie, Muradian Khachik, Fraifeld Vadim

Abstract excerpt

Many mutations that extend the lifespan of the lower organisms such as C. elegans and Drosophila, are associated with signaling or apoptotic pathways. Recently, such a possibility was shown in mammals: p66ShcA-deficient mice were more resistant to oxidative stress and lived longer than the wild-type animals [Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Randolfi, P.P., Lanfrancone, L., Pelicci,...

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Identifiers

PMID: 15621204
DOI: 10.1016/j.mad.2004.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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