Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2005

Cao Jay J, Singleton Patrick A, Majumdar Sharmila, Boudignon Benjamin, Burghardt Andrew, Kurimoto Pam, Wronski Thomas J, Bourguignon Lilly Y W, Halloran Bernard P

Abstract excerpt

UNLABELLED: HA activates CD44 to stimulate RANKL expression in bone marrow stromal cells. HA stimulation of RANKL is blocked by anti-CD44 antibody and is absent in cells from CD44(-/-) mice. CD44(-/-) mice exhibit thicker cortical bone and a smaller medullary cavity, but indices of bone resorption are not affected. INTRODUCTION: Hyaluronan (HA), the major nonprotein glycosaminoglycan component of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Osteoprotegerin
Share to Core Binding Factor Alpha 1 Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyaluronan Receptors

Share to Hyaluronic Acid

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Receptors, Tumor Necrosis Factor

Share to Stromal Cells

Source

Identifiers

PMID: 15619667
DOI: 10.1359/JBMR.041014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44.PMID 15619667Read ↗

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.Semantic proximity Read ↗

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment.Semantic proximity Read ↗

The Role of Hyaluronic Acid in Hemopoietic Stem Cell BiologySemantic proximity Read ↗

The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitroSemantic proximity Read ↗

Modulation of the hyaluronan receptor, CD44, by its transmembrane and cytoplasmic domains.Semantic proximity Read ↗

CD44 mediates hyaluronan to promote the differentiation of human amnionic mesenchymal stem cells into chondrocytes through the activation of Erk1/2 and Smad2 signalsSemantic proximity Read ↗

CD44 in inflammation and metastasis.Semantic proximity Read ↗

CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.Semantic proximity Read ↗

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.Semantic proximity Read ↗

Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis.Semantic proximity Read ↗

Analysis of CD44 interactions with hyaluronan in murine L cell fibroblasts deficient in glycosaminoglycan synthesis: a role for chondroitin sulfate.Semantic proximity Read ↗

Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.