Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.

The Journal of biological chemistry - 9 Mar 2001

Bourguignon L Y, Zhu H, Shao L, Chen Y W

Abstract excerpt

In this study we have demonstrated that both CD44 (the hyaluronan (HA) receptor) and c-Src kinase are expressed in human ovarian tumor cells (SK-OV-3.ipl cell line), and that these two proteins are physically associated as a complex in vivo. Using a recombinant cytoplasmic domain of CD44 and an in vitro binding assay, we have detected a specific interaction between CD44 and c-Src kinase. Furthermore, the binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeleton
Share to Hyaluronan Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyaluronic Acid

Share to Immunoblotting

Share to Microfilament Proteins

Share to Precipitin Tests

Share to Proto-Oncogene Proteins pp60(c-src)

Share to Tyrosine

Source

Identifiers

PMID: 11084024
DOI: 10.1074/jbc.M006498200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.PMID 11084024Read ↗

Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression.Semantic proximity Read ↗

Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.Semantic proximity Read ↗

The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling eventsSemantic proximity Read ↗

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.Semantic proximity Read ↗

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7Semantic proximity Read ↗

Interaction between the Adhesion Receptor, CD44, and the Oncogene Product, p185 , Promotes Human Ovarian Tumor Cell ActivationSemantic proximity Read ↗

Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.Semantic proximity Read ↗

Identification of a novel interaction between integrin beta1 and 14-3-3beta.Semantic proximity Read ↗

Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas).Semantic proximity Read ↗

Modulation of the hyaluronan receptor, CD44, by its transmembrane and cytoplasmic domains.Semantic proximity Read ↗

CD44H regulates tumor cell migration on hyaluronate-coated substrate.Semantic proximity Read ↗

Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.