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Article

Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2005

Asp Lennart, Magnusson Björn, Rutberg Mikael, Li Lu, Borén Jan, Olofsson Sven-Olof

Abstract excerpt

OBJECTIVE: We investigated the role of ADP ribosylation factor 1 (ARF1) in the assembly of very-low-density lipoproteins (VLDLs). METHODS AND RESULTS: The dominant-negative ARF1 mutant, T31N, decreased the assembly of apoB-100 VLDL 1 (Svedberg floatation units [Sf] 60 to 400) by 80%. The decrease coincided with loss of coatamer I (COPI) from the Golgi apparatus and inhibition of anterograde transport, as...

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Identifiers

PMID: 15618550
DOI: 10.1161/01.ATV.0000154135.21689.47

Genes

ARF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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