Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.

Abstract excerpt

Crohn's disease is a chronic, inflammatory disease of the intestinal mucosa. Although intestinal bacteria are implicated in disease pathogenesis, the etiology is still unclear. The main location of disease is the small intestine (ileum) and the colon. Ileal disease has been linked to a mutation in the NOD2 gene. Defensins are antimicrobial peptides and in the ileum, are mainly expressed in Paneth cells,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Crohn Disease
• Share to Defensins
• Share to Gene Expression Regulation