Article
Polymorphism of the angiotensin-converting enzyme gene in end-stage renal failure patients.
Nephron - 1 May 2000
Aucella F, Vigilante M, Margaglione M, Grandone E, del Popolo A, Forcella M, Procaccini D, Salatino G, Passione A, Ktena M, De Min A, Stallone C
Abstract excerpt
The plasma levels of angiotensin-converting enzyme (ACE) are modulated by the insertion (I)/deletion (D) polymorphism within the ACE gene locus. An association between progressive renal disease, raised cardiovascular risk, and ACE plasma levels has been shown. To evaluate the genotype frequencies of the I/D polymorphism in terminal renal failure, we have enrolled 341 dialysis patients (321 on hemodialysis and 20...
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