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Article

Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages.

Infection and immunity - 1 Jan 2005

Donnelly Sheila, O'Neill Sandra M, Sekiya Mary, Mulcahy Grace, Dalton John P

Abstract excerpt

Alternatively activated macrophages (AAMphi) are primarily associated with the chronic stages of parasitic infections and the development of a polarized Th2 response. We have shown that Fasciola hepatica infection of BALB/c mice induces a polarized Th2 response during both the latent and chronic stage of disease. The activation status of macrophages was analyzed in this model of helminth infection by evaluating...

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Identifiers

PMID: 15618151
DOI: 10.1128/IAI.73.1.166-173.2005
PMCID: PMC538930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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