Article
Boosting immunity to treat parasitic infections: Asaia bacteria expressing a protein from Wolbachia determine M1 macrophage activation and killing of Leishmania protozoans.
Pharmacological research - 1 Nov 2020
Varotto-Boccazzi Ilaria, Epis Sara, Arnoldi Irene, Corbett Yolanda, Gabrieli Paolo, Paroni Moira, Nodari Riccardo, Basilico Nicoletta, Sacchi Luciano, Gramiccia Marina, Gradoni Luigi, Tranquillo Vito, Bandi Claudio
Abstract excerpt
Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: hosts displaying M1-polarized macrophages are protected, while those biased on the M2 side acquire...
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