Article
Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.
Infection and immunity - 1 Feb 2010
Dowling David J, Hamilton Clare M, Donnelly Sheila, La Course James, Brophy Peter M, Dalton John, O'Neill Sandra M
Abstract excerpt
Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response. Here we have selected recombinant forms of two major F. hepatica secreted molecules, the protease cathepsin L (rFhCL1) and an antioxidant, sigma class glutathione transferase (rFhGST-si), to examine their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.