Article
[Fluoroquinolone resistance mutations in topoisomerase genes of Salmonella typhimurium isolates].
Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2004
Guo Yunchang, Pei Xiaoyan, Liu Xiumei
Abstract excerpt
OBJECTIVE: Mutations in topoisomerase genes were main cause of the resistence of Salmonella typhimurium to fluoroquinolone. METHODS: The MICs of three Salmonella typhimurium isolates X2, X7, X11 to ciprofloxacin were above 32 microg/ml, 0.38 microg/ml and 0.023 microg/ml, respectively. The genetic alterations in four topoisomerase genes, gyrA, gyrB, parC, and parE were detected by multiplex PCR amplimer...
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